MAJOR MOTOR SEIZURE DISORDER
\mˈe͡ɪd͡ʒə mˈə͡ʊtə sˈiːʒə dɪsˈɔːdə], \mˈeɪdʒə mˈəʊtə sˈiːʒə dɪsˈɔːdə], \m_ˈeɪ_dʒ_ə m_ˈəʊ_t_ə s_ˈiː_ʒ_ə d_ɪ_s_ˈɔː_d_ə]\
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A generalized seizure disorder characterized by recurrent major motor seizures. The initial brief tonic phase is marked by trunk flexion followed by diffuse extension of the trunk and extremities. The clonic phase features rhythmic flexor contractions of the trunk and limbs, pupillary dilation, elevations of blood pressure and pulse, urinary incontinence, and tongue biting. This is followed by a profound state of depressed consciousness (post-ictal state) which gradually improves over minutes to hours. The disorder may be cryptogenic, familial, or symptomatic (caused by an identified disease process). (From Adams et al., Principles of Neurology, 6th ed, p329)
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Dopamine Acetyltransferase
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