RAFAEL OTERO

\ɹˌɑːfa͡ɪˈɛl ɒtˈe͡əɹə͡ʊ], \ɹˌɑːfa‍ɪˈɛl ɒtˈe‍əɹə‍ʊ], \ɹ_ˌɑː_f_aɪ_ˈɛ_l ɒ_t_ˈeə_ɹ_əʊ]\
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1910 - Warner's dictionary of authors ancient and modern
By Charles Dudley Warner

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Platidiam

  • An inorganic water-soluble platinum complex. After undergoing hydrolysis, it reacts DNA produce both intra interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity cisplatin correlates with cellular arrest in G2 phase cell cycle.
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