PROXIMAL RENAL TUBULAR ACIDOSIS
\pɹˈɒksɪmə͡l ɹˈiːnə͡l tjˈuːbjʊləɹ ɐsɪdˈə͡ʊsɪs], \pɹˈɒksɪməl ɹˈiːnəl tjˈuːbjʊləɹ ɐsɪdˈəʊsɪs], \p_ɹ_ˈɒ_k_s_ɪ_m_əl ɹ_ˈiː_n_əl t_j_ˈuː_b_j_ʊ_l_ə_ɹ ɐ_s_ɪ_d_ˈəʊ_s_ɪ_s]\
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A rare sometimes familial disorder of the renal tubule characterized by the inability to excrete urine of normal acidity. This leads to a hyperchloremic acidosis which is often associated with one or more secondary complications such as hypercalcinuria with nephrolithiasis and nephrocalcinosis, rickets, or osteomalacia and severe potassium depletion.
By DataStellar Co., Ltd
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Platidiam
- An inorganic water-soluble platinum complex. After undergoing hydrolysis, it reacts DNA produce both intra interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity cisplatin correlates with cellular arrest in G2 phase cell cycle.