NONSENSE MUTATIONS
\nˈɒnsəns mjuːtˈe͡ɪʃənz], \nˈɒnsəns mjuːtˈeɪʃənz], \n_ˈɒ_n_s_ə_n_s m_j_uː_t_ˈeɪ_ʃ_ə_n_z]\
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A codon that has been converted to the same sequence as a stop codon (CODON, TERMINATOR) by a nonsense mutation. It is different from a stop codon in that it occurs abnormally and causes premature termination of protein translation resulting in the production of truncated proteins which may be non-functional.
By DataStellar Co., Ltd
Word of the day
Platidiam
- An inorganic water-soluble platinum complex. After undergoing hydrolysis, it reacts DNA produce both intra interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity cisplatin correlates with cellular arrest in G2 phase cell cycle.