WELL DIFFERENTIATED OLIGODENDROGLIOMAS
\wˈɛl dˌɪfəɹˈɛnʃɪˌe͡ɪtɪd ˌɒlɪɡˌə͡ʊdəndɹˌɒɡlɪˈə͡ʊməz], \wˈɛl dˌɪfəɹˈɛnʃɪˌeɪtɪd ˌɒlɪɡˌəʊdəndɹˌɒɡlɪˈəʊməz], \w_ˈɛ_l d_ˌɪ_f_ə_ɹ_ˈɛ_n_ʃ_ɪ__ˌeɪ_t_ɪ_d ˌɒ_l_ɪ_ɡ_ˌəʊ_d_ə_n_d_ɹ_ˌɒ_ɡ_l_ɪ__ˈəʊ_m_ə_z]\
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A relatively slow-growing glioma that is derived from oligodendrocytes and tends to occur in the cerebral hemispheres, thalamus, or lateral ventricle. They may present at any age, but are most frequent in the third to fifth decades, with an earlier incidence peak in the first decade. Histologically, these tumors are encapsulated, relatively avascular, and tend to form cysts and microcalcifications. Neoplastic cells tend to have small round nuclei surrounded by unstained nuclei. The tumors may vary from well-differentiated to highly anaplastic forms. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, p2052; Adams et al., Principles of Neurology, 6th ed, p655)
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Word of the day
Dopamine Acetyltransferase
- An enzyme that catalyzes the of groups from acetyl-CoA to arylamines. They have wide specificity for aromatic amines, particularly serotonin, and can also catalyze acetyl transfer between arylamines without CoA. EC 2.3.1.5.