PICROTOXIN
\pˈɪkɹə͡ʊtˌɒksɪn], \pˈɪkɹəʊtˌɒksɪn], \p_ˈɪ_k_ɹ_əʊ_t_ˌɒ_k_s_ɪ_n]\
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A noncompetitive antagonist at GABA-A receptors and thus a convulsant. Picrotoxin blocks the GAMMA-AMINOBUTYRIC ACID-activated chloride ionophore. Although it is most often used as a research tool, it has been used as a CNS stimulant and an antidote in poisoning by CNS depressants, especially the barbiturates.
By DataStellar Co., Ltd
By William R. Warner
By Willam Alexander Newman Dorland
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A very bitter substance, C30H34O12, found in cocculus indicus, of which it forms the active principle. It acts on the nervous centers, and especially on the motor, inhibitory, and respiratory centers of the medulla oblongata. It is used for the night sweats of phthisis, but it probably does more harm than good. It is a dangerous poison, causing convulsions and death by respiratory: paralysis [U. S. Ph., 1890].[Gr.]
By Smith Ely Jelliffe
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