ENKEPHALIN DIPEPTIDYL CARBOXYPEPTIDASE
\ɛnkˈɛfɐlˌɪn dˈa͡ɪpptɪdˌɪl kˈɑːbəksˌa͡ɪpptɪdˌe͡ɪs], \ɛnkˈɛfɐlˌɪn dˈaɪpptɪdˌɪl kˈɑːbəksˌaɪpptɪdˌeɪs], \ɛ_n_k_ˈɛ_f_ɐ_l_ˌɪ_n d_ˈaɪ_p_p_t_ɪ_d_ˌɪ_l k_ˈɑː_b_ə_k_s_ˌaɪ_p_p_t_ɪ_d_ˌeɪ_s]\
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Enzyme that is a major constituent of kidney brush-border membranes and is also present to a lesser degree in the brain and other tissues. It preferentially catalyzes cleavage at the amino group of hydrophobic residues of the B-chain of insulin as well as opioid peptides and other biologically active peptides. The enzyme is inhibited primarily by EDTA, phosphoramidon, and thiorphan and is reactivated by zinc. Neprilysin is identical to common acute lymphoblastic leukemia antigen (CALLA), an important marker in the diagnosis of human acute lymphocytic leukemia. EC 3.4.24.11.
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Platidiam
- An inorganic water-soluble platinum complex. After undergoing hydrolysis, it reacts DNA produce both intra interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity cisplatin correlates with cellular arrest in G2 phase cell cycle.