TOJO HIDEKI

\tˈə͡ʊd͡ʒə͡ʊ hˈa͡ɪdki], \tˈə‍ʊd‍ʒə‍ʊ hˈa‍ɪdki], \t_ˈəʊ_dʒ_əʊ h_ˈaɪ_d_k_i]\
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Platidiam

  • An inorganic water-soluble platinum complex. After undergoing hydrolysis, it reacts DNA produce both intra interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity cisplatin correlates with cellular arrest in G2 phase cell cycle.
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