PARC GENE PRODUCT, TOPO IV
\pˈɑː sˈiː d͡ʒˈiːn pɹˈɒdʌkt], \pˈɑː sˈiː dʒˈiːn pɹˈɒdʌkt], \p_ˈɑː s_ˈiː dʒ_ˈiː_n p_ɹ_ˈɒ_d_ʌ_k_t]\
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A bacterial DNA topoisomerase II that catalyzes ATP-dependent breakage of both strands of DNA, passage of the unbroken strands through the breaks, and rejoining of the broken strands. Topoisomerase IV binds to DNA as a heterotetramer consisting 2 parC and 2 parE subunits. Topoisomerase IV is a decatenating enzyme that resolves interlinked daughter chromosomes following DNA replication.
By DataStellar Co., Ltd
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Platidiam
- An inorganic water-soluble platinum complex. After undergoing hydrolysis, it reacts DNA produce both intra interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity cisplatin correlates with cellular arrest in G2 phase cell cycle.
Nearby Words
- parbreak
- parbuckle
- parbuckled
- parbuckling
- parc gene product
- parC Gene Product, Topo IV
- parc protein
- parcae
- parcase
- parcel
- parcel bomb