HARLEQUIN ICHTHYOSES
\hˈɑːlɪkwˌɪn ˈɪkθɪˌə͡ʊzɪz], \hˈɑːlɪkwˌɪn ˈɪkθɪˌəʊzɪz], \h_ˈɑː_l_ɪ_k_w_ˌɪ_n ˈɪ_k_θ_ɪ__ˌəʊ_z_ɪ_z]\
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A chronic, congenital ichthyosis inherited as an autosomal recessive trait. Infants are usually born encased in a collodion membrane which sheds within a few weeks. Scaling is generalized and marked with grayish-brown quadrilateral scales, adherent at their centers and free at the edges. In some cases, scales are so thick that they resemble armored plate.
By DataStellar Co., Ltd
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Platidiam
- An inorganic water-soluble platinum complex. After undergoing hydrolysis, it reacts DNA produce both intra interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity cisplatin correlates with cellular arrest in G2 phase cell cycle.