GALLIPOLIS, O.
\ɡalˈɪpəlˌɪs], \ɡalˈɪpəlˌɪs], \ɡ_a_l_ˈɪ_p_ə_l_ˌɪ_s]\
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Platidiam
- An inorganic water-soluble platinum complex. After undergoing hydrolysis, it reacts DNA produce both intra interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity cisplatin correlates with cellular arrest in G2 phase cell cycle.