DESIALYLATED GLYCOPROTEINS
\dɪzˈɪɐlˌɪle͡ɪtɪd ɡlˈa͡ɪkəpɹˌə͡ʊtiːnz], \dɪzˈɪɐlˌɪleɪtɪd ɡlˈaɪkəpɹˌəʊtiːnz], \d_ɪ_z_ˈɪ__ɐ_l_ˌɪ_l_eɪ_t_ɪ_d ɡ_l_ˈaɪ_k_ə_p_ɹ_ˌəʊ_t_iː_n_z]\
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Endogenous glycoproteins from which sialic acid has been removed by the action of sialidases. They bind tightly to their cell surface receptor which is located on hepatocyte plasma membranes. After internalization by adsorptive endocytosis they are delivered to lysosomes for degradation. Therefore receptor-mediated clearance of asialoglycoproteins is an important aspect of the turnover of plasma glycoproteins. They are elevated in serum of patients with hepatic cirrhosis or hepatitis.
By DataStellar Co., Ltd
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Platidiam
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