BARE LYMPHOCYTE SYNDROMES
\bˈe͡ə lˈɪmfəsˌa͡ɪt sˈɪndɹə͡ʊmz], \bˈeə lˈɪmfəsˌaɪt sˈɪndɹəʊmz], \b_ˈeə l_ˈɪ_m_f_ə_s_ˌaɪ_t s_ˈɪ_n_d_ɹ_əʊ_m_z]\
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Group of rare congenital disorders characterized by impairment of both humoral and cell-mediated immunity, leukopenia, and low or absent antibody levels. It is inherited as an X-linked or autosomal recessive defect. About half of the patients with autosomal recessive SCID are deficient in the enzyme adenosine deaminase.
By DataStellar Co., Ltd
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Platidiam
- An inorganic water-soluble platinum complex. After undergoing hydrolysis, it reacts DNA produce both intra interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity cisplatin correlates with cellular arrest in G2 phase cell cycle.
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