SAINT GOTHARD'S DISEASE
\sˈe͡ɪnt ɡˈɒθədz dɪzˈiːz], \sˈeɪnt ɡˈɒθədz dɪzˈiːz], \s_ˈeɪ_n_t ɡ_ˈɒ_θ_ə_d_z d_ɪ_z_ˈiː_z]\
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Platidiam
- An inorganic water-soluble platinum complex. After undergoing hydrolysis, it reacts DNA produce both intra interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity cisplatin correlates with cellular arrest in G2 phase cell cycle.