PYRITHIAMINE
\pˈɪɹɪθˌi͡əma͡ɪn], \pˈɪɹɪθˌiəmaɪn], \p_ˈɪ_ɹ_ɪ_θ_ˌiə_m_aɪ_n]\
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A thiamine antagonist due to its inhibition of thiamine pyrophosphorylation. It is used to produce thiamine deficiency.
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Platidiam
- An inorganic water-soluble platinum complex. After undergoing hydrolysis, it reacts DNA produce both intra interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity cisplatin correlates with cellular arrest in G2 phase cell cycle.