KININOGEN CYSTATINS
\kˈɪnɪnəd͡ʒən sˈɪstɐtˌɪnz], \kˈɪnɪnədʒən sˈɪstɐtˌɪnz], \k_ˈɪ_n_ɪ_n_ə_dʒ_ə_n s_ˈɪ_s_t_ɐ_t_ˌɪ_n_z]\
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Endogenous peptides present in most body fluids. Certain enzymes convert them to active KININS which are involved in inflammation, blood clotting, complement reactions, etc. Kininogens belong to the cystatin superfamily. They are cysteine proteinase inhibitors. HIGH-MOLECULAR-WEIGHT KININOGEN; (HMWK); is split by plasma kallikrein to produce BRADYKININ. LOW-MOLECULAR-WEIGHT KININOGEN; (LMWK); is split by tissue kallikrein to produce KALLIDIN.
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