INSERTIONAL ACTIVATION
\ɪnsˈɜːʃənə͡l ˌaktɪvˈe͡ɪʃən], \ɪnsˈɜːʃənəl ˌaktɪvˈeɪʃən], \ɪ_n_s_ˈɜː_ʃ_ə_n_əl ˌa_k_t_ɪ_v_ˈeɪ_ʃ_ə_n]\
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Mutagenesis where the mutation is caused by the introduction of foreign DNA sequences into a gene. This may occur spontaneously in vivo or be experimentally induced in vivo or in vitro. Proviral DNA can be inserted into or adjacent to a cellular proto-oncogene. Insertion of the provirus can cause mutations by interrupting coding sequences or regulatory elements, or cause unregulated expression of the proto-oncogene resulting in tumor formation.
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