EN1639A
\ˈɛn wˈɒn θˈa͡ʊzənd sˈɪkshˈʌndɹədən θˈɜːtinˈa͡ɪn ˈe͡ɪ], \ˈɛn wˈɒn θˈaʊzənd sˈɪkshˈʌndɹədən θˈɜːtinˈaɪn ˈeɪ], \ˈɛ_n w_ˈɒ_n θ_ˈaʊ_z_ə_n_d s_ˈɪ_k_s_h_ˈʌ_n_d_ɹ_ə_d_ə_n θ_ˈɜː_t_i_n_ˈaɪ_n ˈeɪ]\
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Derivative of noroxymorphone that is the N-cyclopropylmethyl congener of NALOXONE. It is a narcotic antagonist that is effective orally, longer lasting and more potent than naloxone, and has been proposed for the treatment of heroin addiction. The FDA has approved naltrexone for the treatment of alcohol dependence.
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Platidiam
- An inorganic water-soluble platinum complex. After undergoing hydrolysis, it reacts DNA produce both intra interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity cisplatin correlates with cellular arrest in G2 phase cell cycle.