DISSEMINATED INTRAVASCULAR COAGULATION
\dɪsˈɛmɪnˌe͡ɪtɪd ˌɪntɹəvˈaskjʊlə kə͡ʊˌaɡjʊlˈe͡ɪʃən], \dɪsˈɛmɪnˌeɪtɪd ˌɪntɹəvˈaskjʊlə kəʊˌaɡjʊlˈeɪʃən], \d_ɪ_s_ˈɛ_m_ɪ_n_ˌeɪ_t_ɪ_d ˌɪ_n_t_ɹ_ə_v_ˈa_s_k_j_ʊ_l_ə k_əʊ_ˌa_ɡ_j_ʊ_l_ˈeɪ_ʃ_ə_n]\
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A disorder characterized by reduction in the elements involved in blood coagulation due to their utilization in widespread blood clotting within the vessels. The activation of the clotting mechanism may arise from any of a number of disorders. In the late stages, it is marked by profuse hemorrhaging. (Dorland, 27th ed)
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Platidiam
- An inorganic water-soluble platinum complex. After undergoing hydrolysis, it reacts DNA produce both intra interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity cisplatin correlates with cellular arrest in G2 phase cell cycle.