CIRCUMSRIPTIVE

\sˌɜːkəmsɹˈɪptɪv], \sˌɜːkəmsɹˈɪptɪv], \s_ˌɜː_k_ə_m_s_ɹ_ˈɪ_p_t_ɪ_v]\
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1790 - A Complete Dictionary of the English Language
By Thomas Sheridan

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Platidiam

  • An inorganic water-soluble platinum complex. After undergoing hydrolysis, it reacts DNA produce both intra interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity cisplatin correlates with cellular arrest in G2 phase cell cycle.
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