CHOKE DAMP
\t͡ʃˈə͡ʊk dˈamp], \tʃˈəʊk dˈamp], \tʃ_ˈəʊ_k d_ˈa_m_p]\
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Platidiam
- An inorganic water-soluble platinum complex. After undergoing hydrolysis, it reacts DNA produce both intra interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity cisplatin correlates with cellular arrest in G2 phase cell cycle.