BULBAR POLIOMYELITIS
\bˈʌlbɑː pˈə͡ʊlɪˌɒmɪɪlˈa͡ɪtɪs], \bˈʌlbɑː pˈəʊlɪˌɒmɪɪlˈaɪtɪs], \b_ˈʌ_l_b_ɑː p_ˈəʊ_l_ɪ__ˌɒ_m_ɪ__ɪ_l_ˈaɪ_t_ɪ_s]\
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A form of paralytic poliomyelitis affecting neurons of the MEDULLA OBLONGATA of the brain stem. Clinical features include impaired respiration, HYPERTENSION, alterations of vasomotor control, and dysphagia. Weakness and atrophy of the limbs and trunk due to spinal cord involvement is usually associated. (From Adams et al., Principles of Neurology, 6th ed, p765)
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Platidiam
- An inorganic water-soluble platinum complex. After undergoing hydrolysis, it reacts DNA produce both intra interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity cisplatin correlates with cellular arrest in G2 phase cell cycle.