BRCA2 PROTEIN
\bˌiːˌɑːsˌiːˈe͡ɪ tˈuː pɹˈə͡ʊtiːn], \bˌiːˌɑːsˌiːˈeɪ tˈuː pɹˈəʊtiːn], \b_ˌiː__ˌɑː_s_ˌiː__ˈeɪ t_ˈuː p_ɹ_ˈəʊ_t_iː_n]\
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A large, nuclear protein, encoded by the BRCA2 gene (GENE, BRCA2). Mutations in this gene predispose humans to breast and ovarian cancer. The BRCA2 protein is an essential component of DNA repair pathways, suppressing the formation of gross chromosomal rearrangements. (from Genes Dev. 2000;14 (11):1400-6)
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Word of the day
Dopamine Acetyltransferase
- An enzyme that catalyzes the of groups from acetyl-CoA to arylamines. They have wide specificity for aromatic amines, particularly serotonin, and can also catalyze acetyl transfer between arylamines without CoA. EC 2.3.1.5.